Study on the Safety and Tolerability of PD-1 Knockout Tumor-infiltrating T Cells (TILs) in the Treatment of Advanced Colorectal Cancer

Conditions

• Colorectal Cancer (CRC)
• Tumor Infiltrating Lymphocytes
• PD-1

Interventions

• BIOLOGICAL: transfusion of 5×10^8 PD-1 knockout TILs per kg body weight
• BIOLOGICAL: transfusion of 1×10^9 PD-1 edited TILs per kg body weight
• BIOLOGICAL: transfusion of 2×10^9 PD-1 edited TILs per kg body weight
• BIOLOGICAL: transfusion of maximum dose without side effects among group A, B and C

Sponsor

Ruijin Hospital