# TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies

> **NCT07052370** · PHASE1 · RECRUITING · sponsor: **St. Jude Children's Research Hospital** · enrollment: 30 (estimated)

## Conditions studied

- Hematologic Malignancy

## Interventions

- **DRUG:** Thymoglobulin
- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine
- **DRUG:** Thiotepa
- **DRUG:** Melphalan
- **DRUG:** Mesna
- **DRUG:** Filgrastim
- **DRUG:** Blinatumomab
- **DEVICE:** CliniMACS

## Key facts

- **NCT ID:** NCT07052370
- **Lead sponsor:** St. Jude Children's Research Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-09-25
- **Primary completion:** 2028-12
- **Final completion:** 2030-12
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2025-12-31


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07052370

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07052370, "TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies". Retrieved via AI Analytics 2026-08-02 from https://api.ai-analytics.org/clinical/NCT07052370. Licensed CC0.

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