# Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

> **NCT07061977** · PHASE3 · RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 336 (estimated)

## Conditions studied

- Locally Advanced Cervical Adenocarcinoma
- Locally Advanced Cervical Adenosquamous Carcinoma
- Locally Advanced Cervical Squamous Cell Carcinoma
- Stage IIIA Cervical Cancer FIGO 2018
- Stage IIIB Cervical Cancer FIGO 2018
- Stage IIIC1 Cervical Cancer FIGO 2018
- Stage IIIC2 Cervical Cancer FIGO 2018
- Stage IVA Cervical Cancer FIGO 2018

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **RADIATION:** Brachytherapy
- **DRUG:** Carboplatin
- **PROCEDURE:** Chest Radiography
- **DRUG:** Cisplatin
- **PROCEDURE:** Computed Tomography
- **RADIATION:** External Beam Radiation Therapy
- **RADIATION:** Intensity-Modulated Radiation Therapy
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Paclitaxel
- **BIOLOGICAL:** Pembrolizumab
- **PROCEDURE:** Positron Emission Tomography

## Key facts

- **NCT ID:** NCT07061977
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-11-05
- **Primary completion:** 2030-12-31
- **Final completion:** 2030-12-31
- **Target enrollment:** 336 (ESTIMATED)
- **Last updated:** 2026-05-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07061977

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07061977, "Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT07061977. Licensed CC0.

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