# Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）

> **NCT07063108** · PHASE4 · NOT_YET_RECRUITING · sponsor: **Chinese PLA General Hospital** · enrollment: 276 (estimated)

## Conditions studied

- Postoperative Pain

## Interventions

- **DRUG:** Esketamine hydrochloride
- **DRUG:** Saline

## Key facts

- **NCT ID:** NCT07063108
- **Lead sponsor:** Chinese PLA General Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-12-01
- **Primary completion:** 2026-06-30
- **Final completion:** 2026-12-31
- **Target enrollment:** 276 (ESTIMATED)
- **Last updated:** 2025-07-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07063108

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07063108, "Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT07063108. Licensed CC0.

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