# Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial

> **NCT07068607** · PHASE4 · RECRUITING · sponsor: **Yongquan Shi** · enrollment: 400 (estimated)

## Conditions studied

- Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer

## Interventions

- **DRUG:** Vonoprazan
- **DRUG:** Tetracycline 500mg tid
- **DRUG:** Minocycline
- **DRUG:** Bismuth
- **DRUG:** Clarithromycin 500 mg
- **DRUG:** Amoxicillin

## Key facts

- **NCT ID:** NCT07068607
- **Lead sponsor:** Yongquan Shi
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-04-01
- **Primary completion:** 2025-10-01
- **Final completion:** 2025-11-01
- **Target enrollment:** 400 (ESTIMATED)
- **Last updated:** 2025-08-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07068607

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07068607, "Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT07068607. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*