# Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL)

> **NCT07072585** · PHASE2,PHASE3 · NOT_YET_RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 1708 (estimated)

## Conditions studied

- Stage II T Lymphoblastic Leukemia/Lymphoma
- Stage III T Lymphoblastic Leukemia/Lymphoma
- Stage IV T Lymphoblastic Leukemia/Lymphoma
- T Acute Lymphoblastic Leukemia
- T Lymphoblastic Lymphoma

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Bone Scan
- **DRUG:** Bortezomib
- **DRUG:** Calaspargase Pegol
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **DRUG:** Cytarabine
- **BIOLOGICAL:** Daratumumab
- **DRUG:** Daunorubicin Hydrochloride
- **DRUG:** Dexamethasone
- **DRUG:** Doxorubicin Hydrochloride
- **PROCEDURE:** Echocardiography Test
- **PROCEDURE:** Lumbar Puncture
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Mercaptopurine Oral Suspension
- **DRUG:** Methotrexate
- **DRUG:** Methylprednisolone

## Key facts

- **NCT ID:** NCT07072585
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-06-28
- **Primary completion:** 2035-09-01
- **Final completion:** 2035-09-01
- **Target enrollment:** 1708 (ESTIMATED)
- **Last updated:** 2025-12-31


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07072585

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07072585, "Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL)". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT07072585. Licensed CC0.

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