# Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer

> **NCT07076485** · PHASE2 · RECRUITING · sponsor: **M.D. Anderson Cancer Center** · enrollment: 768 (estimated)

## Conditions studied

- Breast Cancer

## Interventions

- **RADIATION:** Ultrahypofractionated Radiation
- **RADIATION:** Moderately Hypofractionated Radiation

## Key facts

- **NCT ID:** NCT07076485
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-08-19
- **Primary completion:** 2029-01-01
- **Final completion:** 2031-01-01
- **Target enrollment:** 768 (ESTIMATED)
- **Last updated:** 2026-04-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07076485

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07076485, "Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT07076485. Licensed CC0.

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