# Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.

> **NCT07079761** · PHASE2 · RECRUITING · sponsor: **Massachusetts General Hospital** · enrollment: 96 (estimated)

## Conditions studied

- Post Traumatic Stress Disorder

## Interventions

- **BEHAVIORAL:** Experiment 1: Three-day aversive conditioning, extinction, and extinction retention testing paradigm
- **DRUG:** Allopregnanolone (Allo) with 6% USP Dexolve (sulfobutyl ether-beta-cyclodextrin sodium salt) in 0.9% saline for IV infusion will be provided by the University of California, Davis, GMP manufacturer.
- **BEHAVIORAL:** Experiment 1. Three-day aversive conditioning, extinction, and extinction retention testing paradigm
- **OTHER:** Matching IV Placebo
- **BEHAVIORAL:** Experiment 2. Three-day aversive conditioning, reconsolidation blockade, and testing paradigm
- **DRUG:** Allopregnanolone (Allo) with 6% USP Dexolve (sulfobutyl ether-beta-cyclodextrin sodium salt) in 0.9% saline for IV infusion will be provided by the University of California, Davis, GMP manufacturer.
- **BEHAVIORAL:** Experiment 2. Three-day aversive conditioning, reconsolidation blockade, and testing paradigm
- **OTHER:** Matching IV Placebo

## Key facts

- **NCT ID:** NCT07079761
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-08-04
- **Primary completion:** 2027-04-30
- **Final completion:** 2027-04-30
- **Target enrollment:** 96 (ESTIMATED)
- **Last updated:** 2025-11-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07079761

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07079761, "Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT07079761. Licensed CC0.

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