# Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model

> **NCT07092215** · EARLY_PHASE1 · COMPLETED · sponsor: **Stefan Heber** · enrollment: 42 (actual)

## Conditions studied

- Pain

## Interventions

- **DRUG:** Synthetic interstitial fluid (SIF) / SIF neutral pH
- **DRUG:** Synthetic interstitial fluid (SIF) / SIF acidic pH
- **DRUG:** Synthetic interstitial fluid (SIF) / SIF acidic pH + BCTC 1 µM
- **DRUG:** LPS 5 ng / SIF neutral pH
- **DRUG:** LPS 5 ng / SIF acidic pH
- **DRUG:** LPS 5 ng / SIF acidic pH + BCTC 1 µM
- **DRUG:** LPS 5 ng + Azeliragon 100 µM / SIF neutral pH
- **DRUG:** LPS 5 ng + Azeliragon 100 µM / SIF acidic pH
- **DRUG:** LPS 5 ng + Resatorvid 10 µM / SIF neutral pH
- **DRUG:** LPS 5 ng + Resatorvid 10 µM / SIF acidic pH

## Key facts

- **NCT ID:** NCT07092215
- **Lead sponsor:** Stefan Heber
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2025-06-17
- **Primary completion:** 2025-07-11
- **Final completion:** 2025-07-11
- **Target enrollment:** 42 (ACTUAL)
- **Last updated:** 2025-07-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07092215

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07092215, "Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT07092215. Licensed CC0.

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