# Efficacy of Chronotherapeutic Combination for Major Depressive Episode With Insomnia

> **NCT07120880** · PHASE3 · NOT_YET_RECRUITING · sponsor: **Assistance Publique - Hôpitaux de Paris** · enrollment: 184 (estimated)

## Conditions studied

- Major Depressive Disorder (MDD) With Insomnia

## Interventions

- **PROCEDURE:** AD + SHR + active LT and extended-release melatonin 2mg
- **PROCEDURE:** AD + SHR + active LT and placebo melatonin
- **PROCEDURE:** AD + SHR + placebo LT and extended-release melatonin 2mg
- **PROCEDURE:** AD + SHR + placebo LT and placebo melatonin

## Key facts

- **NCT ID:** NCT07120880
- **Lead sponsor:** Assistance Publique - Hôpitaux de Paris
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-09
- **Primary completion:** 2028-05
- **Final completion:** 2029-05
- **Target enrollment:** 184 (ESTIMATED)
- **Last updated:** 2025-08-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07120880

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07120880, "Efficacy of Chronotherapeutic Combination for Major Depressive Episode With Insomnia". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT07120880. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*