# Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases

> **NCT07134153** · PHASE1,PHASE2 · RECRUITING · sponsor: **Fudan University** · enrollment: 139 (estimated)

## Conditions studied

- Breast Cancer

## Interventions

- **DRUG:** T-DXd

## Key facts

- **NCT ID:** NCT07134153
- **Lead sponsor:** Fudan University
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-04-18
- **Primary completion:** 2026-08-30
- **Final completion:** 2027-02-28
- **Target enrollment:** 139 (ESTIMATED)
- **Last updated:** 2025-08-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07134153

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07134153, "Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT07134153. Licensed CC0.

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