# Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome

> **NCT07135167** · PHASE3 · RECRUITING · sponsor: **Woolfson Eye Institute** · enrollment: 225 (estimated)

## Conditions studied

- Down Syndrome (DS)
- Keratoconus
- Pellucid Marginal Degeneration
- Forme Fruste Keratoconus (FFK)

## Interventions

- **COMBINATION_PRODUCT:** Epi-ON corneal cross-linking (CXL)

## Key facts

- **NCT ID:** NCT07135167
- **Lead sponsor:** Woolfson Eye Institute
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-08-01
- **Primary completion:** 2028-11
- **Final completion:** 2028-12-31
- **Target enrollment:** 225 (ESTIMATED)
- **Last updated:** 2026-02-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07135167

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07135167, "Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT07135167. Licensed CC0.

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