# Clinical and Biochemical Effects Of Cryotherapy Protocols On Mandibular Premolars With Symptomatic Apical Periodontitis

> **NCT07138365** · NA · COMPLETED · sponsor: **Ain Shams University** · enrollment: 180 (actual)

## Conditions studied

- Post Operative Pain
- Inflammation

## Interventions

- **PROCEDURE:** oral Cryotherapy
- **PROCEDURE:** Intra radicular Cryotherapy
- **PROCEDURE:** cold irrigation

## Key facts

- **NCT ID:** NCT07138365
- **Lead sponsor:** Ain Shams University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2024-06-01
- **Primary completion:** 2025-06-01
- **Final completion:** 2025-06-01
- **Target enrollment:** 180 (ACTUAL)
- **Last updated:** 2026-02-11


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07138365

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07138365, "Clinical and Biochemical Effects Of Cryotherapy Protocols On Mandibular Premolars With Symptomatic Apical Periodontitis". Retrieved via AI Analytics 2026-06-16 from https://api.ai-analytics.org/clinical/NCT07138365. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*