# A Non-Inferiority Trial of Stopping Penicillin in Early Rheumatic Heart Disease: GOAL-Stop

> **NCT07146048** · PHASE3 · NOT_YET_RECRUITING · sponsor: **Children's Hospital Medical Center, Cincinnati** · enrollment: 922 (estimated)

## Conditions studied

- Rheumatic Heart Disease

## Interventions

- **DRUG:** Secondary Prophylaxis

## Key facts

- **NCT ID:** NCT07146048
- **Lead sponsor:** Children's Hospital Medical Center, Cincinnati
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-02
- **Primary completion:** 2029-02-20
- **Final completion:** 2029-12-31
- **Target enrollment:** 922 (ESTIMATED)
- **Last updated:** 2025-12-18

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07146048

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07146048, "A Non-Inferiority Trial of Stopping Penicillin in Early Rheumatic Heart Disease: GOAL-Stop". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT07146048. Licensed CC0.

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