# Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression

> **NCT07166289** · NA · RECRUITING · sponsor: **Laureate Institute for Brain Research, Inc.** · enrollment: 140 (estimated)

## Conditions studied

- Treatment-Resistant Depression

## Interventions

- **OTHER:** Low-intensity focused ultrasound

## Key facts

- **NCT ID:** NCT07166289
- **Lead sponsor:** Laureate Institute for Brain Research, Inc.
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-09-30
- **Primary completion:** 2030-04
- **Final completion:** 2030-07
- **Target enrollment:** 140 (ESTIMATED)
- **Last updated:** 2026-03-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07166289

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07166289, "Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT07166289. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*