# Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

> **NCT07195734** · PHASE2 · RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 180 (estimated)

## Conditions studied

- Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Locally Recurrent Head and Neck Squamous Cell Carcinoma
- Locally Recurrent Hypopharyngeal Squamous Cell Carcinoma
- Locally Recurrent Laryngeal Squamous Cell Carcinoma
- Locally Recurrent Oral Cavity Squamous Cell Carcinoma
- Locally Recurrent Oropharyngeal Squamous Cell Carcinoma
- Stage II Laryngeal Cancer AJCC v8
- Stage II Lip and Oral Cavity Cancer AJCC v8
- Stage II Oropharyngeal (p16-Negative) Carcinoma AJCC v8
- Stage III Laryngeal Cancer AJCC v8
- Stage III Lip and Oral Cavity Cancer AJCC v8
- Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8
- Stage IVA Laryngeal Cancer AJCC v8
- Stage IVA Lip and Oral Cavity Cancer AJCC v8
- Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8
- Stage IVB Laryngeal Cancer AJCC v8
- Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **DRUG:** Carboplatin
- **BIOLOGICAL:** Cemiplimab
- **DRUG:** Cisplatin
- **PROCEDURE:** Computed Tomography
- **DRUG:** Paclitaxel
- **PROCEDURE:** Positron Emission Tomography
- **RADIATION:** Radiation Therapy
- **PROCEDURE:** Salvage Surgery

## Key facts

- **NCT ID:** NCT07195734
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-04-24
- **Primary completion:** 2033-02-01
- **Final completion:** 2033-02-01
- **Target enrollment:** 180 (ESTIMATED)
- **Last updated:** 2026-05-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07195734

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07195734, "Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer". Retrieved via AI Analytics 2026-08-09 from https://api.ai-analytics.org/clinical/NCT07195734. Licensed CC0.

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