# Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)

> **NCT07203677** · — · COMPLETED · sponsor: **Brigham and Women's Hospital** · enrollment: 49065 (actual)

## Conditions studied

- Type2 Diabetes Mellitus
- Atherosclerotic Cardiovascular Disease

## Interventions

- **DRUG:** Initiation of tirzepatide
- **DRUG:** Initiation of sitagliptin

## Key facts

- **NCT ID:** NCT07203677
- **Lead sponsor:** Brigham and Women's Hospital
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** COMPLETED
- **Start date:** 2025-09-19
- **Primary completion:** 2025-10-15
- **Final completion:** 2025-10-15
- **Target enrollment:** 49065 (ACTUAL)
- **Last updated:** 2026-04-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07203677

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07203677, "Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT07203677. Licensed CC0.

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