# Ayahuasca and Esketamine for Major Depression

> **NCT07212946** · PHASE2 · COMPLETED · sponsor: **University of Sao Paulo** · enrollment: 22 (actual)

## Conditions studied

- Major Depression Severe

## Interventions

- **DRUG:** Ayahuasca
- **DRUG:** Esketamine

## Key facts

- **NCT ID:** NCT07212946
- **Lead sponsor:** University of Sao Paulo
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-10-30
- **Primary completion:** 2024-10-30
- **Final completion:** 2025-10-01
- **Target enrollment:** 22 (ACTUAL)
- **Last updated:** 2025-12-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07212946

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07212946, "Ayahuasca and Esketamine for Major Depression". Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/clinical/NCT07212946. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*