# Investigating the Evolutionary Impact of Metabolic Flexibility on Physical Activity-Dependent BDNF and Cognition: Insights From the Val66Met Polymorphism

> **NCT07218497** · PHASE1 · NOT_YET_RECRUITING · sponsor: **University of Southern California** · enrollment: 50 (estimated)

## Conditions studied

- Cognition
- BDNF

## Interventions

- **DRUG:** d-beta-hydroxybutrate
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT07218497
- **Lead sponsor:** University of Southern California
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-11-01
- **Primary completion:** 2027-05-01
- **Final completion:** 2027-05-01
- **Target enrollment:** 50 (ESTIMATED)
- **Last updated:** 2025-10-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07218497

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07218497, "Investigating the Evolutionary Impact of Metabolic Flexibility on Physical Activity-Dependent BDNF and Cognition: Insights From the Val66Met Polymorphism". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT07218497. Licensed CC0.

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