# Adding Pirtobrutinib to the Usual Treatment for People With Newly Diagnosed Richter Transformation, The PIRAMID Trial

> **NCT07220187** · PHASE3 · NOT_YET_RECRUITING · sponsor: **SWOG Cancer Research Network** · enrollment: 102 (estimated)

## Conditions studied

- Richter Syndrome
- Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma
- Transformed Small Lymphocytic Lymphoma to Diffuse Large B-Cell Lymphoma

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **DRUG:** Doxorubicin Hydrochloride
- **PROCEDURE:** Echocardiography Test
- **PROCEDURE:** Multigated Acquisition Scan
- **DRUG:** Pirtobrutinib
- **PROCEDURE:** Positron Emission Tomography
- **DRUG:** Prednisone
- **BIOLOGICAL:** Rituximab
- **BIOLOGICAL:** Rituximab and Hyaluronidase Human
- **OTHER:** Survey Administration
- **DRUG:** Vincristine

## Key facts

- **NCT ID:** NCT07220187
- **Lead sponsor:** SWOG Cancer Research Network
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-05-02
- **Primary completion:** 2035-10-01
- **Final completion:** 2036-10
- **Target enrollment:** 102 (ESTIMATED)
- **Last updated:** 2025-10-23

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07220187

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07220187, "Adding Pirtobrutinib to the Usual Treatment for People With Newly Diagnosed Richter Transformation, The PIRAMID Trial". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT07220187. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*