# Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas

> **NCT07222735** · PHASE1 · RECRUITING · sponsor: **St. Jude Children's Research Hospital** · enrollment: 42 (estimated)

## Conditions studied

- Sarcoma
- Childhood Osteosarcoma
- Childhood Rhabdomyosarcoma
- Childhood Soft Tissue Sarcoma
- Ewing Sarcoma

## Interventions

- **DRUG:** Fludarabine
- **DRUG:** Cyclophosphamide
- **DRUG:** B7-H3-CAR T Cells
- **RADIATION:** Radiation Therapy

## Key facts

- **NCT ID:** NCT07222735
- **Lead sponsor:** St. Jude Children's Research Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-01-21
- **Primary completion:** 2030-11-05
- **Final completion:** 2031-11-05
- **Target enrollment:** 42 (ESTIMATED)
- **Last updated:** 2026-02-09


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07222735

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07222735, "Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT07222735. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*