# Methadone in TKA for Post-op Pain and Opioid Reduction

> **NCT07226076** · PHASE3 · RECRUITING · sponsor: **Medical University of South Carolina** · enrollment: 162 (estimated)

## Conditions studied

- Post Operative Pain

## Interventions

- **DRUG:** Methadone Hydrochloride

## Key facts

- **NCT ID:** NCT07226076
- **Lead sponsor:** Medical University of South Carolina
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-01-08
- **Primary completion:** 2026-12-28
- **Final completion:** 2027-01-15
- **Target enrollment:** 162 (ESTIMATED)
- **Last updated:** 2026-02-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07226076

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07226076, "Methadone in TKA for Post-op Pain and Opioid Reduction". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT07226076. Licensed CC0.

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