# Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)

> **NCT07226440** · PHASE1,PHASE2 · RECRUITING · sponsor: **University of California, San Francisco** · enrollment: 50 (estimated)

## Conditions studied

- Toxicant Exposure
- Firefighter
- Occupational Exposure to Chemicals

## Interventions

- **DRUG:** Colesevelam
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT07226440
- **Lead sponsor:** University of California, San Francisco
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-03-01
- **Primary completion:** 2028-12
- **Final completion:** 2028-12
- **Target enrollment:** 50 (ESTIMATED)
- **Last updated:** 2026-04-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07226440

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07226440, "Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT07226440. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*