# Ivonescimab Prior to Surgery for the Treatment of High-Risk Localized Clear Cell Renal Cell Cancer

> **NCT07226544** · PHASE2 · NOT_YET_RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 31 (estimated)

## Conditions studied

- Localized Clear Cell Renal Cell Carcinoma
- Resectable Clear Cell Renal Cell Carcinoma
- Stage II Renal Cell Cancer AJCC v8
- Stage III Renal Cell Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Echocardiography Test
- **BIOLOGICAL:** Ivonescimab
- **PROCEDURE:** Nephrectomy
- **OTHER:** Questionnaire Administration

## Key facts

- **NCT ID:** NCT07226544
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-06-08
- **Primary completion:** 2027-09-08
- **Final completion:** 2027-09-08
- **Target enrollment:** 31 (ESTIMATED)
- **Last updated:** 2025-11-10

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07226544

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07226544, "Ivonescimab Prior to Surgery for the Treatment of High-Risk Localized Clear Cell Renal Cell Cancer". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT07226544. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*