# Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

> **NCT07227415** · PHASE1,PHASE2 · RECRUITING · sponsor: **Pfizer** · enrollment: 224 (estimated)

## Conditions studied

- Carcinoma, Renal Cell
- Advanced Renal Cell Carcinoma
- Renal Cancer
- Renal Neoplasm
- Clear Cell Renal Cell Carcinoma
- Metastatic Renal Cell Carcinoma
- Clear-cell Metastatic Renal Cell Carcinoma
- Carcinoma, Renal Cell Metastasis
- Advanced or Metastatic Renal Cell Carcinoma
- Carcinoma, Renal Cell, Advanced
- Metastatic Renal Cell Cancer
- Metastatic Renal Cell Carcinoma ( mRCC)
- Metastatic/Advanced Renal Cell Carcinoma

## Interventions

- **BIOLOGICAL:** PF-08634404
- **DRUG:** Combination 1
- **DRUG:** Combination 2

## Key facts

- **NCT ID:** NCT07227415
- **Lead sponsor:** Pfizer
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-03-12
- **Primary completion:** 2027-11-02
- **Final completion:** 2028-11-01
- **Target enrollment:** 224 (ESTIMATED)
- **Last updated:** 2026-04-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07227415

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07227415, "Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT07227415. Licensed CC0.

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