# Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

> **NCT07227610** · PHASE2 · RECRUITING · sponsor: **Medical University of South Carolina** · enrollment: 54 (estimated)

## Conditions studied

- Brain Metastases
- Cancer (With CNS Involvement)

## Interventions

- **RADIATION:** Staged Stereotactic Radiosurgery (SSRS)
- **RADIATION:** Fractionated Stereotactic Radiotherapy (FSRT)

## Key facts

- **NCT ID:** NCT07227610
- **Lead sponsor:** Medical University of South Carolina
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-02-03
- **Primary completion:** 2029-02-03
- **Final completion:** 2030-02-03
- **Target enrollment:** 54 (ESTIMATED)
- **Last updated:** 2026-02-05


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07227610

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07227610, "Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT07227610. Licensed CC0.

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