# Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With Myelofibrosis and Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes

> **NCT07228624** · PHASE2 · RECRUITING · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 50 (estimated)

## Conditions studied

- Myelodysplastic/Myeloproliferative Neoplasm
- Primary Myelofibrosis
- Secondary Myelofibrosis

## Interventions

- **DRUG:** Ruxolitinib
- **PROCEDURE:** Allogeneic Hematopoietic Stem Cell Transplantation
- **DRUG:** Busulfan
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **PROCEDURE:** Echocardiography Test
- **DRUG:** Fludarabine
- **DRUG:** JAK Inhibitor
- **DRUG:** Melphalan
- **DRUG:** Methotrexate
- **DRUG:** Tacrolimus
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy

## Key facts

- **NCT ID:** NCT07228624
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-02-04
- **Primary completion:** 2030-09-01
- **Final completion:** 2030-09-01
- **Target enrollment:** 50 (ESTIMATED)
- **Last updated:** 2026-02-19

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07228624

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07228624, "Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With Myelofibrosis and Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes". Retrieved via AI Analytics 2026-07-12 from https://api.ai-analytics.org/clinical/NCT07228624. Licensed CC0.

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