# Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized, Phase II Trial

> **NCT07230639** · PHASE2 · RECRUITING · sponsor: **Sixth Affiliated Hospital, Sun Yat-sen University** · enrollment: 52 (estimated)

## Conditions studied

- Neoadjuvant Therapies
- Immune Checkpoint Therapy
- Radiotherapy

## Interventions

- **COMBINATION_PRODUCT:** Node-Sparing Radiotherapy(25Gy/5F) plus Chemotherapy and PD-1 inhibitor
- **COMBINATION_PRODUCT:** Node-Sparing Radiotherapy(24Gy/4F) plus Chemotherapy and PD-1 inhibitor

## Key facts

- **NCT ID:** NCT07230639
- **Lead sponsor:** Sixth Affiliated Hospital, Sun Yat-sen University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-08-30
- **Primary completion:** 2030-08-29
- **Final completion:** 2031-12-31
- **Target enrollment:** 52 (ESTIMATED)
- **Last updated:** 2025-12-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07230639

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07230639, "Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized, Phase II Trial". Retrieved via AI Analytics 2026-09-22 from https://api.ai-analytics.org/clinical/NCT07230639. Licensed CC0.

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