# Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study

> **NCT07247968** · EARLY_PHASE1 · RECRUITING · sponsor: **Min Su** · enrollment: 220 (estimated)

## Conditions studied

- Esketamine
- ECT
- Depression
- Adolescent

## Interventions

- **DRUG:** Esketamine injection group (0.25 mg/kg)
- **OTHER:** Saline injection group (Consistent with esketamine injection volume)

## Key facts

- **NCT ID:** NCT07247968
- **Lead sponsor:** Min Su
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-11-25
- **Primary completion:** 2026-11-20
- **Final completion:** 2026-12-20
- **Target enrollment:** 220 (ESTIMATED)
- **Last updated:** 2026-01-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07247968

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07247968, "Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT07247968. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*