# Sustained Mood Improvement With Laughing Gas Exposure

> **NCT07262008** · PHASE3 · NOT_YET_RECRUITING · sponsor: **Women's College Hospital** · enrollment: 120 (estimated)

## Conditions studied

- Major Depressive Disorder
- Treatment Resistant Depression

## Interventions

- **DRUG:** Inhalation of Nitrous oxide (Laughing gas) + intravenous saline
- **DRUG:** inhalation of %100 oxygen + intravenous midazolam

## Key facts

- **NCT ID:** NCT07262008
- **Lead sponsor:** Women's College Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-02-01
- **Primary completion:** 2027-02-01
- **Final completion:** 2028-09-01
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2025-12-10

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07262008

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07262008, "Sustained Mood Improvement With Laughing Gas Exposure". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT07262008. Licensed CC0.

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