# Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA)

> **NCT07262957** · PHASE4 · RECRUITING · sponsor: **Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)** · enrollment: 400 (estimated)

## Conditions studied

- Pancreas Head Cancer
- Pancreas Adenocarcinoma
- IPMN, Pancreatic
- Cholangio Carcinoma
- Ampulla of Vater Adenocarcinoma
- PDAC - Pancreatic Ductal Adenocarcinoma
- Duodenal Carcinoma
- Mucinous Cystic Neoplasm
- Neuro Endocrine Tumours
- Pancreatitis

## Interventions

- **COMBINATION_PRODUCT:** HOP bundle

## Key facts

- **NCT ID:** NCT07262957
- **Lead sponsor:** Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-09-01
- **Primary completion:** 2027-09-01
- **Final completion:** 2027-12-01
- **Target enrollment:** 400 (ESTIMATED)
- **Last updated:** 2025-12-22

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07262957

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07262957, "Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA)". Retrieved via AI Analytics 2026-07-08 from https://api.ai-analytics.org/clinical/NCT07262957. Licensed CC0.

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