# Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial

> **NCT07271355** · PHASE3 · NOT_YET_RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 129 (estimated)

## Conditions studied

- Metastatic Appendix Carcinoma
- Metastatic Colorectal Carcinoma
- Metastatic Malignant Neoplasm in the Peritoneum
- Stage IV Appendix Carcinoma AJCC v8
- Stage IVC Colorectal Cancer AJCC v8
- Unresectable Colorectal Carcinoma

## Interventions

- **BIOLOGICAL:** Bevacizumab
- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **DRUG:** Fluorouracil
- **DRUG:** Irinotecan Hydrochloride
- **DRUG:** Leucovorin Calcium
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Mitomycin
- **OTHER:** Questionnaire Administration

## Key facts

- **NCT ID:** NCT07271355
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-07-01
- **Primary completion:** 2031-02-28
- **Final completion:** 2031-02-28
- **Target enrollment:** 129 (ESTIMATED)
- **Last updated:** 2025-12-09

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07271355

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07271355, "Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial". Retrieved via AI Analytics 2026-07-12 from https://api.ai-analytics.org/clinical/NCT07271355. Licensed CC0.

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