# Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients

> **NCT07271849** · PHASE4 · RECRUITING · sponsor: **Qianfoshan Hospital** · enrollment: 162 (estimated)

## Conditions studied

- Postoperative Pain, Acute
- Hemodynamics
- Total Knee Arthroplasty (TKA)

## Interventions

- **DRUG:** Nalbuphine Hydrochloride injection was administered during anesthesia induction.
- **DRUG:** Nalbuphine Hydrochloride injection was administered after cement implantation.
- **OTHER:** Standard general anesthesia regimen ( nalbuphine was not administered throughout the entire anesthesia process.)

## Key facts

- **NCT ID:** NCT07271849
- **Lead sponsor:** Qianfoshan Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-10-28
- **Primary completion:** 2026-10-01
- **Final completion:** 2026-10-31
- **Target enrollment:** 162 (ESTIMATED)
- **Last updated:** 2025-12-09


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07271849

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07271849, "Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients". Retrieved via AI Analytics 2026-07-06 from https://api.ai-analytics.org/clinical/NCT07271849. Licensed CC0.

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