# Image-Guidance and Online Adaptation With Stereotactic Body Radiation Therapy for the Treatment of Localized Prostate Cancer, MANTICORE Trial

> **NCT07276438** · NA · RECRUITING · sponsor: **Jonsson Comprehensive Cancer Center** · enrollment: 186 (estimated)

## Conditions studied

- Localized Prostate Adenocarcinoma
- Stage I Prostate Cancer AJCC v8
- Stage II Prostate Cancer AJCC v8
- Stage III Prostate Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **RADIATION:** CT-guided Stereotactic Body Radiation Therapy
- **OTHER:** Inter-fraction Adaptation of Treatment Plan
- **PROCEDURE:** Magnetic Resonance Imaging
- **RADIATION:** MRI-guided Stereotactic Body Radiation Therapy
- **OTHER:** Survey Administration

## Key facts

- **NCT ID:** NCT07276438
- **Lead sponsor:** Jonsson Comprehensive Cancer Center
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-12-01
- **Primary completion:** 2031-12-31
- **Final completion:** 2032-12-31
- **Target enrollment:** 186 (ESTIMATED)
- **Last updated:** 2026-02-05

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07276438

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07276438, "Image-Guidance and Online Adaptation With Stereotactic Body Radiation Therapy for the Treatment of Localized Prostate Cancer, MANTICORE Trial". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT07276438. Licensed CC0.

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