# Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)

> **NCT07284641** · PHASE2 · RECRUITING · sponsor: **Paul Szabolcs** · enrollment: 25 (estimated)

## Conditions studied

- Common Variable Immunodeficiency (CVID)
- Primary Immune Regulatory Disorder
- Immune Dysregulation
- DiGeorge Syndrome
- STAT 1 Gain of Function
- STAT 3 Gain of Function
- Hypomorphic RAG1 Deficiency
- CD40 Ligand Deficiency
- Mendelian Susceptibility to Mycobacterial Disease
- GATA2 Associated Immunodeficiency
- CD40 Deficiency
- Hypomorphic RAG2 Deficiency
- Immune Dysregulation Polyendocrinopathy Enteropathy X-Linked Syndrome
- Omenn Syndrome
- Chronic Granulomatous Disease

## Interventions

- **BIOLOGICAL:** Hematopoietic stem cell transplant (HSCT)

## Key facts

- **NCT ID:** NCT07284641
- **Lead sponsor:** Paul Szabolcs
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-05-04
- **Primary completion:** 2030-05-04
- **Final completion:** 2031-02-01
- **Target enrollment:** 25 (ESTIMATED)
- **Last updated:** 2026-05-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07284641

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07284641, "Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)". Retrieved via AI Analytics 2026-07-02 from https://api.ai-analytics.org/clinical/NCT07284641. Licensed CC0.

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