# A Trial to Investigate Whether Oral Arsenic Trioxide Is Similar to Intravenous Arsenic Trioxide in Pharmacokinetics, Safety, and Efficacy (LATITUDE/SDKARS-301)

> **NCT07296445** · PHASE3 · NOT_YET_RECRUITING · sponsor: **SDK Therapeutics, Inc.** · enrollment: 120 (estimated)

## Conditions studied

- Acute Promyelocytic Leukemia (APL)
- Acute Promyelocytic Leukaemia
- Acute Promyelocytic Leukemia With PML-RARA
- Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA
- APL
- Acute Promyelocytic Leukemia
- Leukaemia
- Leukemia Acute Promyelocytic Leukemia (APL)
- Leukemia, Acute

## Interventions

- **DRUG:** Oral ATO
- **DRUG:** IV Arsenic Trioxide
- **DRUG:** all-trans retinoic acid (ATRA)

## Key facts

- **NCT ID:** NCT07296445
- **Lead sponsor:** SDK Therapeutics, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-01
- **Primary completion:** 2027-06
- **Final completion:** 2029-01
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2025-12-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07296445

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07296445, "A Trial to Investigate Whether Oral Arsenic Trioxide Is Similar to Intravenous Arsenic Trioxide in Pharmacokinetics, Safety, and Efficacy (LATITUDE/SDKARS-301)". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT07296445. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*