GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma

NCT07301268 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

36

Enrollment

OTHER

Sponsor class

Conditions

Glioblastoma, IDH-Wildtype
Progressive Astrocytoma, IDH-Mutant, Grade 4
Progressive Glioblastoma
Progressive Gliosarcoma
Recurrent Astrocytoma, IDH-Mutant, Grade 4
Recurrent Glioblastoma, IDH-Wildtype
Recurrent Gliosarcoma
Resectable Astrocytoma
Resectable Glioblastoma

Interventions

PROCEDURE: Biospecimen Collection
DRUG: Bispecific CD80-lgG4Fc-IL-2v Fusion Protein GI-102
PROCEDURE: Computed Tomography
PROCEDURE: Echocardiography Test
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Multigated Acquisition Scan
BIOLOGICAL: Pembrolizumab
PROCEDURE: Surgical Procedure

Sponsor

Mayo Clinic