# De-Escalation Surgery After Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

> **NCT07320690** · PHASE3 · NOT_YET_RECRUITING · sponsor: **Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University** · enrollment: 356 (estimated)

## Conditions studied

- Squamous Cell Carcinoma of the Head and Neck

## Interventions

- **PROCEDURE:** De-escalation surgery
- **PROCEDURE:** Standard Surgery
- **RADIATION:** radiotherapy
- **DRUG:** adjuvant immunotherapy

## Key facts

- **NCT ID:** NCT07320690
- **Lead sponsor:** Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-01-01
- **Primary completion:** 2031-07-01
- **Final completion:** 2031-07-01
- **Target enrollment:** 356 (ESTIMATED)
- **Last updated:** 2026-01-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07320690

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07320690, "De-Escalation Surgery After Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT07320690. Licensed CC0.

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