# Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonide 0.01%, Tretinoin 0.025%) in Treatment of Melasma in Tertiary Care Hospital Karachi

> **NCT07345507** · NA · COMPLETED · sponsor: **Jinnah Postgraduate Medical Centre** · enrollment: 34 (actual)

## Conditions studied

- Melasma

## Interventions

- **DRUG:** Metformin gel, 30%
- **DRUG:** Triple combination cream (hydroquinone 2% + tretinoin 0.025% + fluocinolone acetonide 0.01%)
- **DRUG:** Broad-spectrum sunscreen (SPF ≥30)

## Key facts

- **NCT ID:** NCT07345507
- **Lead sponsor:** Jinnah Postgraduate Medical Centre
- **Sponsor class:** OTHER_GOV
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2025-02-01
- **Primary completion:** 2025-08-30
- **Final completion:** 2025-08-30
- **Target enrollment:** 34 (ACTUAL)
- **Last updated:** 2026-01-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07345507

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07345507, "Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonide 0.01%, Tretinoin 0.025%) in Treatment of Melasma in Tertiary Care Hospital Karachi". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT07345507. Licensed CC0.

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