# Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression

> **NCT07374211** · NA · NOT_YET_RECRUITING · sponsor: **Chinese PLA General Hospital** · enrollment: 242 (estimated)

## Conditions studied

- Depression
- Anxiety
- S-ketamine
- Breast Cancer

## Interventions

- **DRUG:** Esketamine 0.3mg/kg
- **DRUG:** normal saline

## Key facts

- **NCT ID:** NCT07374211
- **Lead sponsor:** Chinese PLA General Hospital
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-01-18
- **Primary completion:** 2026-01-18
- **Final completion:** 2027-02-01
- **Target enrollment:** 242 (ESTIMATED)
- **Last updated:** 2026-01-28


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07374211

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07374211, "Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT07374211. Licensed CC0.

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