# B7-H3.CD28Z.CART in CNS Neoplasms

> **NCT07390539** · PHASE1 · NOT_YET_RECRUITING · sponsor: **Robbie Majzner** · enrollment: 70 (estimated)

## Conditions studied

- Central Nervous System Neoplasms
- Brain Tumor
- Brain Tumor, Recurrent
- Brain Tumor, Pediatric
- Brain Tumor Adult
- Medulloblastoma
- Medulloblastoma, Childhood
- Medulloblastoma, Adult
- Medulloblastoma Recurrent
- Ependymoma
- Atypical Teratoid/Rhabdoid Tumor
- Embryonal Tumor With Multilayered Rosettes
- Pineoblastoma
- Leptomeningeal Disease

## Interventions

- **BIOLOGICAL:** B7-H3.CD28Z.CART
- **DRUG:** Fludarabine
- **DRUG:** Cyclophosphamide

## Key facts

- **NCT ID:** NCT07390539
- **Lead sponsor:** Robbie Majzner
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-07
- **Primary completion:** 2030-08-31
- **Final completion:** 2032-08-31
- **Target enrollment:** 70 (ESTIMATED)
- **Last updated:** 2026-02-05

## Collaborators

- National Institutes of Health (NIH)

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07390539

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07390539, "B7-H3.CD28Z.CART in CNS Neoplasms". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT07390539. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*