# Biomarkers of Response to SEEG Thermocoagulation

> **NCT07399327** · NA · NOT_YET_RECRUITING · sponsor: **Assistance Publique Hopitaux De Marseille** · enrollment: 45 (estimated)

## Conditions studied

- Drug Resistant Epilepsy

## Interventions

- **OTHER:** Quality of life questionnaires (QOLIE, EFIQUACEE for children), psychiatric questionnaires (NDDIE, GAD-7, PCL-5) at Visit 1 (V1), V5, V6 and V7
- **OTHER:** Resting state SEEG recording 30min before and 30 min after RFTC
- **OTHER:** Blood sample at Visit 1 (V1), V2, V4 and V5
- **OTHER:** SEEG electrodes tissue-traces sample at V3 (during SEEG electrodes ablation)
- **OTHER:** Multiparametric 3T MRI with gadolinium at V1, V4 and V5
- **OTHER:** Multiparametric 7T MRI at V1 and V5

## Key facts

- **NCT ID:** NCT07399327
- **Lead sponsor:** Assistance Publique Hopitaux De Marseille
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-03-01
- **Primary completion:** 2029-01-31
- **Final completion:** 2029-06-30
- **Target enrollment:** 45 (ESTIMATED)
- **Last updated:** 2026-02-10

## Collaborators

- [object Object]
- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07399327

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07399327, "Biomarkers of Response to SEEG Thermocoagulation". Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/clinical/NCT07399327. Licensed CC0.

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