Study on the Safety and Efficacy of Intratympanic Injection of Small Extracellular Vesicles Derived From Mesenchymal Stem Cells in Severe and Profound Sudden Sensorineural Hearing Loss

Conditions

• Sudden Hearing Loss
• Extracellular Vesicles

Interventions

• DRUG: Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at low doses
• DRUG: Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at moderate doses
• DRUG: Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at high doses
• DRUG: Standard treatment for sudden deafness+hUC-MSC-sEV-003 at an appropriate dose as determined by stage I trial
• DRUG: Standard treatment for sudden deafness+dexamethasone

Sponsor

The Affiliated Hospital of Qingdao University