# Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

> **NCT07405086** · PHASE4 · RECRUITING · sponsor: **OHSU Knight Cancer Institute** · enrollment: 160 (estimated)

## Conditions studied

- Advanced Biliary Tract Carcinoma
- Advanced Head and Neck Squamous Cell Carcinoma
- Advanced Hepatocellular Carcinoma
- Advanced Lung Non-Small Cell Carcinoma
- Advanced Malignant Solid Neoplasm
- Advanced Melanoma
- Advanced Renal Cell Carcinoma
- Metastatic Biliary Tract Carcinoma
- Metastatic Head and Neck Squamous Cell Carcinoma
- Metastatic Hepatocellular Carcinoma
- Metastatic Lung Non-Small Cell Carcinoma
- Metastatic Malignant Solid Neoplasm
- Metastatic Melanoma
- Metastatic Renal Cell Carcinoma
- Recurrent Head and Neck Squamous Cell Carcinoma
- Stage III Hepatocellular Carcinoma AJCC v8
- Stage III Lung Cancer AJCC v8
- Stage III Renal Cell Cancer AJCC v8
- Stage IV Hepatocellular Carcinoma AJCC v8
- Stage IV Lung Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **DRUG:** Immune Checkpoint Inhibitor

## Key facts

- **NCT ID:** NCT07405086
- **Lead sponsor:** OHSU Knight Cancer Institute
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-05-05
- **Primary completion:** 2028-12-31
- **Final completion:** 2028-12-31
- **Target enrollment:** 160 (ESTIMATED)
- **Last updated:** 2026-05-05

## Collaborators

- Oregon Health and Science University

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07405086

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07405086, "Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT07405086. Licensed CC0.

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