# Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment

> **NCT07405476** · PHASE2 · RECRUITING · sponsor: **Emory University** · enrollment: 38 (estimated)

## Conditions studied

- Colon Carcinoma
- Colorectal Carcinoma
- Rectal Carcinoma
- Stage I Colon Cancer AJCC v8
- Stage I Colorectal Cancer AJCC v8
- Stage I Rectal Cancer AJCC v8
- Stage II Colon Cancer AJCC v8
- Stage II Colorectal Cancer AJCC v8
- Stage II Rectal Cancer AJCC v8
- Stage III Colon Cancer AJCC v8
- Stage III Colorectal Cancer AJCC v8
- Stage III Rectal Cancer AJCC v8

## Interventions

- **BIOLOGICAL:** Zanidatamab
- **PROCEDURE:** Resection
- **OTHER:** Patient Observation
- **PROCEDURE:** Echocardiography Test
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Endoscopic Procedure
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Digital Rectal Examination
- **OTHER:** Electronic Health Record Review

## Key facts

- **NCT ID:** NCT07405476
- **Lead sponsor:** Emory University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-04-07
- **Primary completion:** 2028-12-18
- **Final completion:** 2029-12-18
- **Target enrollment:** 38 (ESTIMATED)
- **Last updated:** 2026-04-17

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07405476

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07405476, "Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT07405476. Licensed CC0.

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