# PRO-BOOST-LC: Whole-Gland Boost Strategies Versus SBRT Monotherapy in PSMA-Staged Localized and Locally Advanced Prostate Cancer

> **NCT07426055** · PHASE2,PHASE3 · RECRUITING · sponsor: **Affidea Nu-med Center of Oncological DIagnostics and Therapy** · enrollment: 1200 (estimated)

## Conditions studied

- Prostate Cancer (Adenocarcinoma)
- Prostate Brachytherapy
- Stereotactic Body Radiation Therapy (SBRT)
- Dose Escalation: Solid Tumors
- Localized Prostate Cancer

## Interventions

- **RADIATION:** Stereotactic Body Radiotherapy (SBRT) Monotherapy
- **RADIATION:** External Beam Radiotherapy (EBRT) Backbone
- **RADIATION:** High-Dose-Rate Brachytherapy Boost
- **RADIATION:** Low-Dose-Rate Brachytherapy Boost
- **RADIATION:** Stereotactic Body Radiotherapy (SBRT) Boost
- **DRUG:** Androgen Deprivation Therapy (ADT)

## Key facts

- **NCT ID:** NCT07426055
- **Lead sponsor:** Affidea Nu-med Center of Oncological DIagnostics and Therapy
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-03-19
- **Primary completion:** 2033-12
- **Final completion:** 2035-12
- **Target enrollment:** 1200 (ESTIMATED)
- **Last updated:** 2026-03-23


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07426055

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07426055, "PRO-BOOST-LC: Whole-Gland Boost Strategies Versus SBRT Monotherapy in PSMA-Staged Localized and Locally Advanced Prostate Cancer". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT07426055. Licensed CC0.

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