# Modulation of Stem Cell Differentiation in Individuals With High Risk Clonal Haematopoiesis

> **NCT07435636** · PHASE2 · NOT_YET_RECRUITING · sponsor: **Clinical Hub for Interventional Research (CHOIR)** · enrollment: 80 (estimated)

## Conditions studied

- Clonal Cytopenia of Uncertain Significance
- CCUS Clonal Cytopenia of Undetermined Significance
- Clonal Hematopoiesis

## Interventions

- **DRUG:** Oral Decitabine and Tetrahydrouridine
- **DRUG:** Matched Placebo (Capsules)

## Key facts

- **NCT ID:** NCT07435636
- **Lead sponsor:** Clinical Hub for Interventional Research (CHOIR)
- **Sponsor class:** OTHER_GOV
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-04-13
- **Primary completion:** 2030-04-14
- **Final completion:** 2030-10
- **Target enrollment:** 80 (ESTIMATED)
- **Last updated:** 2026-02-27

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07435636

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07435636, "Modulation of Stem Cell Differentiation in Individuals With High Risk Clonal Haematopoiesis". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT07435636. Licensed CC0.

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