# Cryotherapy and Intracanal Medicaments for Postoperative Pain in Apical Periodontitis

> **NCT07437612** · PHASE2 · COMPLETED · sponsor: **Celalettin Topbaş** · enrollment: 80 (actual)

## Conditions studied

- Periapical Periodontitis, Chronic Nonsuppurative

## Interventions

- **DRUG:** Placement of calcium hydroxide as an intracanal medicament
- **DRUG:** Placement of metformin as an intracanal medicament
- **DRUG:** Application of calcium hydroxide as an intracanal medicament together with intracanal cryotherapy
- **DRUG:** Application of metformin into the canal together with intracanal cryotherapy

## Key facts

- **NCT ID:** NCT07437612
- **Lead sponsor:** Celalettin Topbaş
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-02-13
- **Primary completion:** 2024-01-01
- **Final completion:** 2024-01-01
- **Target enrollment:** 80 (ACTUAL)
- **Last updated:** 2026-02-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07437612

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07437612, "Cryotherapy and Intracanal Medicaments for Postoperative Pain in Apical Periodontitis". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT07437612. Licensed CC0.

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