# Lesion-Allocated Therapy for Multiple Metastases and Tumor-Zoned Treatment for Bulky Tumors: A Phase II Study of Iodine-125 Seed Implantation Combined With Cryoablation in High-Burden Metastatic Disease

> **NCT07437625** · PHASE2 · NOT_YET_RECRUITING · sponsor: **Li Min** · enrollment: 90 (estimated)

## Conditions studied

- High-Burden Metastatic Solid Tumors

## Interventions

- **PROCEDURE:** Iodine-125 (125I) Seed Implantation (Low-Dose-Rate Brachytherapy)
- **PROCEDURE:** cryoablation
- **OTHER:** Lesion Allocation and Tumor Zoning Strategy

## Key facts

- **NCT ID:** NCT07437625
- **Lead sponsor:** Li Min
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-02
- **Primary completion:** 2027-07-01
- **Final completion:** 2028-07-01
- **Target enrollment:** 90 (ESTIMATED)
- **Last updated:** 2026-02-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07437625

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07437625, "Lesion-Allocated Therapy for Multiple Metastases and Tumor-Zoned Treatment for Bulky Tumors: A Phase II Study of Iodine-125 Seed Implantation Combined With Cryoablation in High-Burden Metastatic Disease". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT07437625. Licensed CC0.

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