# DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.

> **NCT07440290** · PHASE2,PHASE3 · NOT_YET_RECRUITING · sponsor: **Cancer Research UK** · enrollment: 30 (estimated)

## Conditions studied

- Haematological Malignancy
- Malignant Neoplasm
- Lymphoproliferative Disorders
- Neoplasms by Histologic Type
- Neoplasms by Site
- Gastrointestinal Cancer
- Non-Melanoma Skin Cancer (NMSC)
- Langerhans Cell Histiocytosis (LCH)
- Cancer
- Erdheim-Chester Disease
- Thyroid Carcinoma, Papillary
- Ovarian Neoplasms
- Colorectal Neoplasms
- Laryngeal Neoplasms
- Carcinoma, Non-Small Cell-Lung
- Glioma
- Multiple Myeloma
- Thyroid Carcinoma, Anaplastic
- Solid Tumour

## Interventions

- **DRUG:** Dabrafenib
- **DRUG:** Trametinib

## Key facts

- **NCT ID:** NCT07440290
- **Lead sponsor:** Cancer Research UK
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-02
- **Primary completion:** 2029-10
- **Final completion:** 2029-10
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2026-02-27

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07440290

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07440290, "DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT07440290. Licensed CC0.

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